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Reversible airflow obstruction: Treatment of acute exacerbations of symptoms and reversible airflow obstruction due to asthma or other chronic lung diseases eg, emphysema, chronic bronchitis as an adjunct to inhaled beta-2 selective agonists and systemically administered corticosteroids. Theophylline extended-release tablets are recommended for chronic or long-term management and prevention of symptoms, and not for use in treating acute symptoms of asthma and reversible bronchospasm. Always consult a healthcare professional for medical advice.

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This medication may interfere with certain lab tests such as blood sugar, cholesterol, uric acid, dipyridamole-thallium imaging tests possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug. Have persistent nighttime symptoms. Older adults may be more likely to have side effects from theophylline.

SD where actual range not reported

Enoxacin interferes with the of theophylline, resulting in a dose-related decrease in theophylline clearance. Elevated theophylline concentrations may increase the risk of theophylline-related adverse reactions. Cardiovascular side effects have included increases in heart rate which have progressed to supraventricular tachycardia or ventricular tachycardia. Patients with a history of arrhythmias may be predisposed to this effect. Hypotension has occurred with rapid intravenous administration. For various North American patient populations from literature reports. Different rates of elimination and consequent dosage requirements have been observed among other peoples.

Loading dose: IV: Refer to adult dosing

COPD treatment: Theophylline is currently considered second-line intravenous therapy in the emergency department or hospital setting when there is inadequate or insufficient response to short acting bronchodilators Global Initiative for COPD Guidelines 2013. Table III. Drugs that have been documented not to interact with theophylline or drugs that produce no clinically significant interaction with theophylline. Refer to PRECAUTIONS, Drug Interactions for information regarding table. COPD may be more susceptible to the respiratory depressant effects of anticonvulsants. Theophylline passes freely across the placenta, into breast milk and into the cerebrospinal fluid CSF. Saliva theophylline concentrations approximate unbound serum concentrations, but are not reliable for routine or therapeutic monitoring unless special techniques are used. An increase in the volume of distribution of theophylline, primarily due to reduction in plasma protein binding, occurs in premature neonates, patients with hepatic cirrhosis, uncorrected acidemia, the elderly and in women during the third trimester of pregnancy.



Reviews for theophylline

Serum Concentrations at Steady-State: After multiple doses of Theophylline, steady-state is reached in 30-65 hours average 40 hours in adults. At steady- state, on a dosage regimen with 6-hour intervals, the expected mean trough concentration is approximately 60% of the mean peak concentration, assuming a mean Theophylline half-life of 8 hours. The difference between peak and trough concentrations is larger in patients with more rapid Theophylline clearance. In patients with high Theophylline clearance and half-lives of about 4-5 hours, such as children age 1 to 9 years, the trough serum Theophylline concentration may be only 30% of peak with a 6-hour dosing interval. Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. LDL ratio, and urinary free cortisol excretion may be increased by theophylline. Theophylline may decrease triiodothyronine. Lithium: Theophylline Derivatives may decrease the serum concentration of Lithium. Gender Gender differences in theophylline clearance are relatively small and unlikely to be of clinical significance. Significant reduction in theophylline clearance, however, has been reported in women on the 20th day of the menstrual cycle and during the third trimester of pregnancy. Monitor the patient and obtain a serum Theophylline concentration in 2-4 hours to insure that the concentration is not increasing. There are no adequate and well controlled studies in pregnant women. Theophylline required to achieve a therapeutic serum Theophylline concentration will be larger. Discontinuation of a concomitant drug that increases Theophylline clearance will result in accumulation of Theophylline to potentially toxic levels, unless the Theophylline dose is appropriately reduced. Discontinuation of a concomitant drug that inhibits Theophylline clearance will result in decreased serum Theophylline concentrations, unless the Theophylline dose is appropriately increased. Gastrointestinal side effects have included anorexia, nausea, vomiting, and abdominal pain. Aminophylline may also cause locally-mediated gastrointestinal upset.



Theophylline forms and strengths

Other quinolones also produce erosions of cartilage of weight-bearing joints and other signs of arthropathy in immature animals of various species. Dispense in tight, light-resistant container. Label "shake well". Stable for 90 days at room temperature. United States are appropriate, unless specifically indicated otherwise. Marchlinski FE, Miller JM "Atrial arrhythmias exacerbated by theophylline: response to verapamil and evidence for triggered activity in man. Combining guarana with polyphenols may have a similar effect. The safety of using guarana for weight loss is unknown. Average effect on steady-state Theophylline concentration or other clinical effect for pharmacologic interactions. There is also an injectable medication approved for asthma, called omalizumab Xolair or anti-IgE therapy. This medication binds to the antibody type responsible for allergic reactions immunoglobulin E or IgE in the bloodstream and is indicated for severe, allergic asthma not controlled with any of the other available asthma medications. This medication must always be administered in a health-care setting. Formoterol. Theophylline Derivatives may enhance the hypokalemic effect of Formoterol. ZYFLO and terfenadine is not recommended. Hall RC, Beresford TP, Stickney SK, et al "Psychiatric reactions produced by respiratory drugs. mircette



Theophylline ingredients

Most serum theophylline assays in clinical use are immunoassays which are specific for theophylline. Other xanthines such as caffeine, dyphylline, and pentoxifylline are not detected by these assays. The Effect of Other Drugs on Theophylline Serum Concentration Measurements: Most serum Theophylline assays in clinical use are immunoassays which are specific for Theophylline. Other xanthines such as caffeine, dyphylline, and pentoxifylline are not detected by these assays. Co-administration of Theophylline with food or antacids does not cause clinically significant changes in the absorption of Theophylline from immediate-release dosage forms. Note: Serum Theophylline concentrations may continue to increase after presentation of the patient for medical care. Race: Pharmacokinetic differences in Theophylline clearance due to race have not been studied. Off-label use: For reversal of adenosine-, dipyridamole-, or regadenoson-induced adverse events during nuclear cardiac stress testing, administer IV undiluted over 30 to 60 seconds, repeat as necessary. THE SAFETY AND EFFECTIVENESS OF ENOXACIN IN PATIENTS AND ADOLESCENTS UNDER THE AGE OF 18 YEARS WOMEN, AND LACTATING WOMEN HAVE NOT BEEN ESTABLISHED. If the serum sample is drawn more or less than twelve 12 hours after the dose, the results must be interpreted with caution since the concentration may not be reflective of the peak concentration. In contrast, when signs or symptoms of theophylline toxicity are present, the serum sample should be obtained as soon as possible, analyzed immediately, and the result reported to the healthcare professional without delay. AtoMOXetine: May enhance the hypertensive effect of Sympathomimetics. AtoMOXetine may enhance the tachycardic effect of Sympathomimetics. Theophylline extended-release tablets are contraindicated in patients with a history of hypersensitivity to Theophylline or other components in the product. Cross-resistance with other quinolones has been demonstrated. buy now cheapest linezolid payment linezolid



How to use theophylline

Therapy with theophyllines should be administered cautiously in patients presenting with one or more of these risk factors, and the dosage should be appropriately reduced to prevent toxicity. More intensive monitoring of serum theophylline concentrations may be required. In patients with chronic asthma, including patients with severe asthma requiring inhaled corticosteroids or alternate-day oral corticosteroids, many clinical studies have shown that theophylline decreases the frequency and severity of symptoms, including nocturnal exacerbations, and decreases the "as needed" use of inhaled beta 2 agonists. Theophylline has also been shown to reduce the need for short courses of daily oral prednisone to relieve exacerbations of airway obstruction that are unresponsive to bronchodilators in asthmatics. CATEGORY C: There are no adequate and well controlled studies in pregnant women. Terzian CG, Simon PA "Aminophylline hypersensitivity apparently due to ethylenediamine. Crush one 300 mg extended release tablet in a mortar and reduce to a fine powder. The information on this page is not a substitute for the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that a drug or drug combination is safe, effective or appropriate for any given patient. Drugs. Theophylline can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Quinolones, including enoxacin, decrease the clearance of R-warfarin, the less active isomer of racemic warfarin. Enoxacin does not affect the clearance of the active S-isomer, and changes in clotting time have not been observed when enoxacin and warfarin were coadministered. Nevertheless, the time or other suitable test should be monitored when warfarin or its derivatives and enoxacin are given concomitantly.



Theophylline drug interactions

What should I discuss with my healthcare provider before taking theophylline Uniphyl? Yellow No. 6, fruit flavor, purified water and saccharin sodium. May contain sodium citrate for pH adjustment. Significant reduction in theophylline clearance has been reported in women on the 20th day of the menstrual cycle and during the third trimester of pregnancy. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Asthma exacerbations: The treatment of asthma exacerbations with theophylline is not supported or recommended by current clinical practice guidelines GINA 2016; NAEPP 2007. Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. Consider 10% dose reduction in infusion rate to improve safety margin even if dose is tolerated. The majority of side effects have been dependent on the serum concentration. Cannabinoid-Containing Products: May enhance the tachycardic effect of Sympathomimetics. Exceptions: Cannabidiol. After multiple doses of theophylline, steady state is reached in 30-65 hours average 40 hours in adults. At steady state, on a dosage regimen with 6-hour intervals, the expected mean trough concentration is approximately 60% of the mean peak concentration, assuming a mean theophylline half-life of 8 hours. The difference between peak and trough concentrations is larger in patients with more rapid theophylline clearance. In patients with high theophylline clearance and half-lives of about 4-5 hours, such as children age 1 to 9 years, the trough serum theophylline concentration may be only 30% of peak with a 6-hour dosing interval. Stop infusion for 12 hours and decrease subsequent infusion rate at least 25%. If symptomatic, stop infusion and consider whether overdose treatment is indicated. Phenytoin increases Theophylline clearance by increasing microsomal enzyme activity. Theophylline decreases phenytoin absorption. Enoxacin plasma half-life is 3 to 6 hours. If side effects still bother you and you wonder if you should keep taking the medicine, call your doctor. He or she may be able to lower your dose or change your medicine. Ophthalmologic abnormalities, including cataracts and multiple punctate lenticular opacities, have been noted in patients undergoing treatment with enoxacin, as well as with some other quinolones, but have also been observed in patients receiving in comparative trials. In using multiple-dose therapy, levels of enoxacin and other quinolones were significantly higher than respective concentrations. The causal relationship, if any, of quinolones to lenticular abnormalities has not been established. mail order effexor canada effexor



What other drugs will affect theophylline?

American Journal of Clinical Dermatology: “A randomized, placebo-controlled trial of topical retinol in the treatment of cellulite. Distribution: Once Theophylline enters the systemic circulation, about 40% is bound to plasma protein, primarily albumin. Unbound Theophylline distributes throughout body water, but distributes poorly into body fat. In patients with COPD clinical studies have shown that theophylline decreases dyspnea, air trapping, the work of breathing, and improves contractility of diaphragmatic muscles with little or no improvement in pulmonary function measurements. Shannon M "Predictors of major toxicity after theophylline overdose. Experts have not studied guarana extensively. So far, studies have not found that guarana is helpful for improving cognitive ability or mood. Some people use guarana to boost athletic or sexual performance. Thiabendazole: May decrease the metabolism of Theophylline Derivatives. What should I discuss with my healthcare provider before taking theophylline? Discuss the risks and benefits with your doctor. Changes in your body during the last may affect the amount of this drug in your blood. Your doctor should carefully monitor the amount of drug in your blood, as well as any side effects, so that your dose may be changed if needed. May lower theophylline seizure threshold. purchase hytrin indicacao



Theophylline side effects

Patients should be instructed not to continue any dosage that causes adverse effects and to withhold subsequent doses until the symptoms have resolved, at which time the healthcare professional may instruct the patient to resume the drug at a lower dosage see Dosing Guidelines, Table VI. Theophylline can cause side effects that may impair your thinking or reactions. It is essential that serum Theophylline concentrations be monitored before and after transfer to once-daily dosing. To guide a dose increase, the blood sample should be obtained at the time of the expected peak serum theophylline concentration; 1-2 hours after a dose at steady-state. For most patients, steady-state will be reached after 3 days of dosing when no doses have been missed, no extra doses have been added, and none of the doses have been taken at unequal intervals. Race Pharmacokinetic differences in theophylline clearance due to race have not been studied. P-450 1A2 and 3A3 activity. So a person with COPD who continues to smoke may need larger doses of the medicine. Table I. Mean and range of total body clearance and half-life of Theophylline related to age and altered physiological states. At the high dose, systemic toxicity was observed in both species including decreases in testicular weight. The most common causes of chronic theophylline overdosage include patient or care giver error in dosing, healthcare professional prescribing of an excessive dose or a normal dose in the presence of factors known to decrease the rate of theophylline clearance, and increasing the dose in response to an exacerbation of symptoms without first measuring the serum theophylline concentration to determine whether a dose increase is safe. Theophylline also strengthens right heart function and movement. Theophylline was approved by the FDA in April 1979. Patient may experience agitation, insomnia, or polyuria. Have patient report immediately to prescriber signs of low potassium muscle pain or weakness, muscle cramps, or an abnormal heartbeat signs of high blood sugar confusion, fatigue, increased thirst, increased hunger, polyuria, flushing, fast breathing, or breath that smells like fruit muscle pain, muscle weakness, tachycardia, abnormal heartbeat, fast breathing, severe dizziness, passing out, severe anxiety, nausea, vomiting, severe diarrhea, abdominal pain, severe headache, confusion, seizures, or tremors HCAHPS. Larger diazepam doses may be required to produce desired level of sedation. Discontinuation of theophylline without reduction of diazepam dose may result in respiratory depression. Caution is advised when using this drug in children because they may be more sensitive to its effects. Careful monitoring of side effects, drug levels, and dose adjustment is recommended. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc.



List of theophylline side effects

Case reports of Theophylline overdose in humans and animal studies suggest that phenytoin is ineffective in terminating Theophylline-induced seizures. The doses of benzodiazepines and phenobarbital required to terminate Theophylline-induced seizures are close to the doses that may cause severe respiratory depression or respiratory arrest; the healthcare professional should therefore be prepared to provide assisted ventilation. Elderly patients and patients with COPD may be more susceptible to the respiratory depressant effects of anticonvulsants. Barbiturate-induced coma or administration of general anesthesia may be required to terminate repetitive seizures or status epilepticus. General anesthesia should be used with caution in patients with Theophylline overdose because fluorinated volatile anesthetics may sensitize the myocardium to endogenous catecholamines released by Theophylline. Enflurane appears less likely to be associated with this effect than halothane and may, therefore, be safer. Neuromuscular blocking agents alone should not be used to terminate seizures since they abolish the musculoskeletal manifestations without terminating seizure activity in the brain. Theophylline decreases phenytoin 40%. Gender differences in theophylline clearance are relatively small and unlikely to be of clinical significance. Significant reduction in theophylline clearance, however, has been reported in women on the 20th day of the menstrual cycle and during the third trimester of pregnancy. Decreases theophylline clearance by inhibiting cytochrome P450 1A2. Theophylline Oral Solution USP is a clear red solution with a berry flavor. Each tablespoonful 15 mL contains 80 mg theophylline anhydrous. Pediatric Use: Safety and effectiveness in pediatric patients and adolescents below the age of 18 years have not been established. Enoxacin causes arthropathy in animals. Allopurinol: May increase the serum concentration of Theophylline Derivatives. Get medical help right away if you have any very serious side effects, including: seizures. Increased frequency of nausea, nervousness, and insomnia. Other medicines may be a better choice than methylxanthines for treating COPD, because the dose needed to improve symptoms is so close to a dose that causes serious side effects. CYP1A2 Inducers Strong: May increase the metabolism of CYP1A2 Substrates. Management: Consider an alternative for one of the interacting drugs. Some combinations may be specifically contraindicated. Consult appropriate manufacturer labeling. Mexiletine: May decrease the metabolism of Theophylline Derivatives. order real eldepryl



How to take theophylline

Combination controller medications exist for patients whose asthma symptoms are not well controlled on inhaled corticosteroids alone. If you suspect that certain foods are for you, discuss this with your doctor. can be done to determine if you are allergic to these foods. What Do I Do If I Have Food Allergies and Asthma? Enoxacin did not induce point mutations in cells or conversion in cells, with or without activation. Enoxacin did not induce sister chromatid exchanges or structural chromosomal aberrations in mammalian cells in vitro, with or without metabolic activation. In addition, enoxacin did not induce chromosomal aberrations in mice. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. True RJ, Berman JM, Mahutte CK. Treatment of theophylline toxicity with oral activated charcoal. Decrease dose by 25%even if no adverse effects are present. Smokers Tobacco and marijuana smoking appears to increase the clearance of theophylline by induction of metabolic pathways. Theophylline clearance has been shown to increase by approximately 50% in young adult tobacco smokers and by approximately 80% in elderly tobacco smokers compared to non-smoking subjects. Passive smoke exposure has also been shown to increase theophylline clearance by up to 50%. Abstinence from tobacco smoking for one week causes a reduction of approximately 40% in theophylline clearance. Careful attention to dose reduction and frequent monitoring of serum theophylline concentrations are required in patients who stop smoking see . Use of nicotine gum has been shown to have no effect on theophylline clearance. iwomi.info ciprofloxacin



What are the possible side effects of theophylline

The volume of distribution is also increased during the third trimester. Monitor serum levels. The recommendations for the use of theophylline in pregnant women with asthma are similar to those used in nonpregnant adults National Heart, Lung, and Blood Institute Guidelines 2004. Serum Theophylline concentrations may continue to increase after presentation of the patient for medical care as a result of continued absorption of Theophylline from the gastrointestinal tract. Serial monitoring of serum Theophylline serum concentrations should be continued until it is clear that the concentration is no longer rising and has returned to non-toxic levels. Pediatrics: The clearance of Theophylline is very low in neonates see . Theophylline clearance reaches maximal values by one year of age, remains relatively constant until about 9 years of age and then slowly decreases by approximately 50% to adult values at about age 16. Renal excretion of unchanged Theophylline in neonates amounts to about 50% of the dose, compared to about 10% in children older than three months and in adults. Once theophylline enters the systemic circulation, about 40% is bound to plasma protein, primarily albumin. Unbound theophylline distributes throughout body water, but distributes poorly into body fat. The dose of your medicine may need to be adjusted. Recheck serum concentration after three days for further dosage adjustment. Guarana is derived from the seeds of a South American tree. Due to the immaturity of theophylline metabolic pathways in infants under the age of one year, particular attention to dosage selection and frequent monitoring of serum theophylline concentrations are required when theophylline is prescribed to pediatric patients in this age group. Miscellaneous: Other factors associated with decreased Theophylline clearance include the third trimester of pregnancy, sepsis with multiple organ failure, and hypothyroidism. Careful attention to dose reduction and frequent monitoring of serum Theophylline concentrations are required in patients with any of these conditions see . Other factors associated with increased Theophylline clearance include hyperthyroidism and cystic fibrosis. Avoid the Food Trigger. Try not to come into contact with the food you are allergic to. Avoiding food triggers can be challenging. It is important to always read food labels and, when dining out, ask how foods are prepared. Theo-24 Extended-release capsules meet Drug Release Test 6 as published in the current USP monograph for Theophylline Extended-release Capsules.



Use of theophylline

Patients who metabolize theophylline at a normal or slow rate are reasonable candidates for once-daily dosing with Theo-24. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. Phenobarbital may cause respiratory depression, particularly in elderly patients and patients with COPD. What is the most important information I should know about theophylline Elixophyllin, Theo-24? About 6% of a Theophylline dose is N-methylated to caffeine. Fosphenytoin: May decrease the serum concentration of Theophylline Derivatives. Theophylline Derivatives may decrease the serum concentration of Fosphenytoin. Management: Seek alternatives when possible. Spirometry. A test that measures lung function as you breathe in and out of a mouthpiece that is attached to a device called a spirometer. Theophylline clearance may be further reduced by concomitant diseases prevalent in the elderly, which further impair clearance of this drug and have the potential to increase serum levels and potential toxicity. Theophylline. The clinical importance of these changes should be weighed against the potential therapeutic benefit of Theophylline in individual patients. Quinolone-class adverse reactions: Although not reported in completed clinical studies with enoxacin, a variety of adverse events have been reported with other quinolones. pramipexole



Theophylline warnings

Dosage adjustment based on serum theophylline concentrations: Note: Recheck serum theophylline concentration 24 hours after dosage adjustment. Toda K, Goriki K, Ochiai M, Tokunou H, Uehara S, Takahashi H, Okusaki K "Gout due to xanthine derivatives. Consult your doctor before -feeding. Theophylline toxicity: If a patient develops signs and symptoms of theophylline toxicity eg, persistent, repetitive vomiting a serum level should be measured and subsequent doses held. Is theophylline available as a generic drug? This is an older asthma medication that is not used as frequently today as in the past. This medication acts to open the airways bronchodilate and also improves inflammation in the lung due to immune cells activated in asthma. Theophylline is usually used in combination with other asthma medications. Its use is often limited by potential side effects that are not a concern with other asthma medications. Additionally, GINA guidelines do not recommend oral theophylline for asthma in children 6 to 11 years of age. Some theophylline side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Journal of Cosmetic and Laser Therapy: “Effects of cellulite treatment with RF, IR light, mechanical massage and suction treating one buttock with the contralateral as a control. Children up to age 4 are usually treated a little differently than those 5 to 11 years old. Reported range or estimated range mean 2 SD where actual range not reported. Dennis RJ, Solarte I 2011. Asthma in adults chronic search date April 2010. BMJ Clinical Evidence. Also called radiofrequency systems, they show promise for cellulite. combivent



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Indications and usage of theophylline


Theophylline brand names

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Cardiovascular disease: Use with caution in patients with cardiac arrhythmias excluding bradyarrhythmias; use may exacerbate arrhythmias. generic suprax mail order otc

What other drugs will affect theophylline

Clearance: Note: Maturation of clearance in premature infants and term infants is most closely related to postconceptional age PCA; adult clearance values are reached at approximately 55 weeks PCA and higher pediatric values at approximately 60 weeks PCA Kraus1993. These medicines may be given together in the case of an overdose of theophylline. Your doctor may check blood levels for theophylline. The dose of theophylline may be adjusted or given two to three hours before the charcoal to prevent a decreased effect if the charcoal is not being given for a theophylline overdose. Theophylline is a bronchodilator. It works by relaxing muscles in the lungs and chest, making the lungs less sensitive to allergens and other causes of bronchospasm.

About theophylline

Theophylline is available as pills, capsules, liquid, and injection. Medscape: “Cord-Cutting Technique Smooths Cellulite for 3 Years. The time of peak serum level varied from subject to subject, occurring from 4 to 14 hours after dosing. However, 92% of the subjects had serum levels at least 75% of the maximum value at 4 to 8 hours after dosing, during each phase. Theophylline clearance for up to 24 hours. benadryl liquid canada

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Different brands of theophylline get into the bloodstream at different rates. So always use the same generic or brand-name medicine. Elevated serum CK-MB levels have been associated with theophylline toxicity in the absence of cardiac disease. CK-MB levels have returned to normal following discontinuation of theophylline therapy. Shannon M, Amitai Y, Lovejoy FH Jr. Multiple dose activated charcoal for theophylline poisoning in young infants. Do not use this medication if you are allergic to theophylline. Serum theophylline and phenytoin concentrations decrease about 40%.

Cardiovascular side effects have included increased heart rate which has progressed to atrial tachycardia or ventricular tachycardia. Patients with a history of arrhythmias may be predisposed to this effect. Hypotension has occurred with rapid intravenous administration. What other drugs will affect theophylline Uniphyl? Hagley MT, Traeger SM, Schuckman H "Pronounced metabolic response to modest theophylline overdose. tolterodine

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